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Orlistat

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Orlistat is a long-acting and potent specific gastrointestinal lipase inhibitor. It is white or off-white powder at room temperature. It is insoluble in water, soluble in chloroform, and easily soluble in ethanol. It passes through the stomach and small intestine cavity. Intragastric lipase and pancreatic lipase active codon form a covalent bond to inactivate the enzyme. Fat in food cannot be broken down into free fatty acids and monoacylglycerols, so the fat cannot be absorbed and utilized, thereby reducing the body's caloric intake and controlling body weight. This medicine does not need to be absorbed through the body to exert its effects. At the usual dose, fat absorption can be suppressed by 30%. It is rarely absorbed after oral administration and can be metabolized and inactivated in the intestine. The metabolic site is on the wall of the gastrointestinal tract, and the elimination half-life is about 14 to 19 hours. About 97% of this product is excreted with feces, of which 83% is excreted in the original form.

Orlistat can be used clinically for obesity and hyperlipidemia. Under normal circumstances, 120mg can be taken orally once a day, three times a day, and taken within one hour after a meal. After taking the medicine for 2 weeks, the weight may start to decrease. It can be taken continuously for 6 to 12 months. If the dose is increased to more than 400 mg per day, its effect will no longer be enhanced.

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